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I recently wrote a paper titled: The Microbiome Theory of Aging, which was published in the peer-reviewed medical journalIntegrative Medicine, which can be accessed by clicking on the link below:
ABSTRACT: The Microbiome Theory of Aging (MTA) explains how microbial imbalance in the intestinal tract, (also called dysbiosis), causes health problems that accelerate biological aging. The underlying mechanisms involved include increased inflammation, elevated levels of zonulin, destruction of intestinal tight junctions, and intestinal permeability, which allow lipopolysaccharides (LPS) to leak into systemic circulation. LPS is a powerful endotoxin that causes chronic inflammation throughout the body. Chronic inflammation is associated with chronic diseases and the acceleration of biological aging. Postbiotic metabolites are compounds that are created by probiotic bacteria in the colon. Postbiotic metabolites have been called the new frontier in microbiome science due to their key roles in regulating the structure and function of the gut microbiome and many aspects of human health.