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For those of you who don’t know me, my name is Ross Pelton, and I am The Natural Pharmacist. My website, blog and bio are at naturalpharmacist.net
I am initiating a GoFundMe campaign to raise $10,000 for the publication of my new book titled: RAPAMYCIN: The World’s #1 Life Extension Drug & Other Key Life Extension Therapies. The generic name for rapamycin is sirolimus.
This blog post contains the book’s Table of Contents, Chapter 1 which is the introduction and Chapter 2, which lists key bullet points about rapamycin. This will provide individuals who are considering investing, more information about the book’s content and the importance of this information. By making a donation, you will accelerate your learning curve about life extension drugs, nutrients and therapies that can improve your health, slow down your aging process and result in healthy life extension for you and your loved ones NOW.
If you invest, you will be joining me in the Life Extension Revolution.
RAPAMYCIN: The World’s #1 Life Extension Drug
& Other Key Life Extension Therapies
By Ross Pelton, The Natural Pharmacist
TABLE OF CONTENTS
Chapter 1: Introduction
Chapter 2: Key bullet points summarizing rapamycin.
Chapter 3: History & discovery of rapamycin
Chapter 4: Mechanisms of Action: understanding mTOR, autophagy and calorie restriction
Chapter 5: Calorie restriction and Intermittent fasting
Chapter 6: Summary of Rapamycin’s Health Benefits & Safety Profile
Chapter 7: How to ask your doctor to write a rapamycin prescription for you
Dosage, directions & how & where to get your rapamycin prescription filled
Chapter 8: Summarizing the Importance of Rapamycin, mTOR & Autophagy
Chapter 9: The Science: links to key scientific studies, articles and podcast
Chapter 10: Alan Green, MD: Utilizing Rapamycin in the Prevention &
Treatment of Aging and Age-Related Diseases in over 700 patients
My top recommendations for other important life extension therapies:
Chapter 11: BEMER: Increasing micro-capillary circulation & pulsed electro-
magnetic frequencies (PEMF)
Chapter 12: Dr. Ohhira’s Probiotics: maintaining a healthy microbiome
Chapter 13: Metformin: A True Anti-Aging Drug
Chapter 14: The Importance of: boosting glutathione levels
Chapter 15: Crystal-free coenzyme Q10
Chapter 16: Far Infrared Saunas
Chapter 17: Hydrogen-rich water (HRW)
Chapter 18: Vitamin D
Chapter 19: Exercise
Chapter 20: Diet
About the Author:
Chapter 1: Introduction
This book is the story of rapamycin, which is the most effective life extension drug that has ever been discovered. Rapamycin works by shifting the body’s cellular biochemistry into a mode that mimics calorie restriction. This sets a cascade of beneficial effects in motion at the cellular level, which improve health, delay the onset of many diseases, and increase lifespan. My original goal was to just write about rapamycin. However, I eventually decided to discuss several other drugs, nutrients and products that are strong candidates to be classified as life therapies (chapters 11-20).
Rapamycin has resulted in substantial life extension in every species it has been tested on. Numerous studies in animals taking rapamycin report 50-60% increases in lifespan. Also, studies in aged mice suggest that rapamycin started late in life will also result in improved health and life extension in humans. When 20-month-old mice (equal to about 65 years old in humans) were started on rapamycin, the result revealed life extension of 14% for females and 9% for males.
In 1935, a landmark study was published, which reported that laboratory rats placed on a calorie restricted diet, while maintaining adequate nutrition, lived 33% longer than previously known possible. Since that time, many experiments on a wide range of animals have confirmed that calorie restricted diets, without malnutrition, can achieve significant increases in lifespan. Rapamycin mimics calorie restriction.
Rapamycin is a compound that is produced by a strain of bacteria named Streptomyces rapamycinicus (formerly Streptomyces hygroscopicus). This bacterium was discovered from soil samples taken during a scientific expedition to Easter Island in 1964. The purpose of this scientific expedition was to search for compounds that might express antifungal and/or antibiotic properties.
Efforts to market rapamycin as an antifungal drug were discontinued when it was discovered to have potent immunosuppressive activity. Subsequently, rapamycin was approved by the FDA in September 1999 as a drug to prevent organ transplant rejection.
Additional studies revealed that rapamycin also exhibits a broad range of other functions, which include inhibiting the growth cancerous tumors, neuroprotective and neuro-regenerative activity, and life extension. Due to the promising results of these initial studies, samples of rapamycin were sent to the U.S. National Cancer Institute (NCI) for testing and confirmation.
Initial tests at the National Cancer Institute revealed that rapamycin had strong activity against all solid tumors. Subsequently, the NCI elevated rapamycin to “priority drug” status because of its impressive anti-cancer activity and because it functioned differently than most anticancer drugs.
Many anticancer drugs are classified as ‘cytotoxic drugs’ because they kill rapidly dividing cancer cells. However, cytotoxicity causes a wide range of side effects because other rapidly dividing cells such as bone marrow cells and cells lining the intestinal tract also sustain significant damage. Rapamycin appeared to be a totally new type of anticancer drug because it functioned by inhibiting cancer growth (cytostatic) rather than by killing cancer cells (cytotoxic).
LIFE EXTENSION: The most exciting news about rapamycin is in the field of life extension. Rapamycin has produced important health improvements and/or significant life extension in every species tested thus far, which includes yeast, worms, fruit flies and mice. The results of these studies suggest that rapamycin is the most effective life extension drug ever discovered.
An important factor in rapamycin’s favor is the fact scientists now understand how and why rapamycin produces so many beneficial effects. Rapamycin functions by binding to an enzyme named mTOR. The mTOR signaling pathway regulates mechanisms the production of proteins and processes of cellular growth and metabolism. However, when mTOR is inhibited, it enables another critical process named autophagy to function. Autophagy is a process that results in detoxification and revitalization of cells; it is critical to the life of every cell in the body. mTOR and autophagy are explained in chapter 4.
Current life extension clinical trials are underway with dogs, marmosets (a tiny monkey that only lives to about eight years old), and humans. Regarding testing rapamycin in humans, in June of 2021, a crowdfunding project successfully raised $183 million for the first human rapamycin clinical trial. This is called the PEARL trial, which stands for The Participatory Evaluation (of) Aging (with) Rapamycin (for) Longevity Study.
My goals for writing this book are the following:
a. I want to provide readers with a summary of the history, development, and benefits of rapamycin so that you understand its potential benefit for you and your loved ones.
b. I want to “coach” readers on how to use this information to educate your physician about rapamycin and give you pointers on how to go about asking your physician to write you rapamycin prescription.
c. I will discuss dosages, directions, side effects (it is quite safe) and how to find a pharmacy that will fill your prescription for rapamycin.
d. I will provide links to key scientific studies, articles, and podcast interviews on rapamycin
Here’s to increasing your healthy longevity. Ross The Natural Pharmacist
Chapter 2: Key Bullet Points Summarizing Rapamycin.
Rapamycin is an antifungal/antibiotic drug that was discovered in 1964; first study published in 1975 as an antifungal agent.
Rapamycin was approved by the FDA in September 1999 as a drug to prevent organ transplant rejection.
Mechanism of action:
a. Inhibits the signaling pathway named mTOR (explanation in Part 4)
b. Mimics calorie restriction
c. Activates autophagy; the body’s repair, regeneration and healing mechanism
Rapamycin has been used safely in humans for decades; it is FDA approved for prevention of organ transplant rejection, as a treatment for certain types of cancer and in patients receiving cardiac stents.
First rapamycin life extension study: rapamycin given to 20-month-old (elderly) mice increased median lifespan of females 14% and males 9%. In a subsequent trial with 9-month-old (young) mice given 3x greater dose of rapamycin, median lifespan increased 26% in females and 23% in males.
In 2006, Dr. Mikhail Blagosklonny was the first to propose that “rapamycin could be used immediately to slow down aging and all age-related diseases in humans, thus becoming an “anti-aging drug today.”
Rapamycin is administered every day to inhibit rejection in organ transplant patients; when it is given at lower doses (once weekly) rapamycin improves many health metrics, which results in life extension.
Rapamycin has produced significant life extension in every species tested including yeast, worms, fruit flies, and mice. Currently clinical trials are also being conducted in dogs, and marmosets (a tiny primate/monkey that only lives to about eight years old).
The first ever human rapamycin life extension trial (PEARL trial) has been funded and will begin soon. PEARL stands for the Participatory Evaluation (of) Aging (with) Rapamycin (for) Longevity Study. This study was funded in a Crowdfunding campaign that raised $183 million.
Explosion of rapamycin research: From the first published rapamycin study in 1975 until 2008, there were fewer than 10 published papers per year on the topic of “rapamycin and aging.” However, from 2009 through 2016, approximately 180 papers/year have been published on rapamycin and aging. A PubMed search on July 1, 2021 showed 6,221 listings with the word rapamycin in the title.
KEY BENEFITS of TAKING RAPAMYCIN
Taking rapamycin helps all cells in the body begin to function better; it slows the process of aging. Improvements are reported in a wide range of chronic degenerative diseases.
The most commonly reported benefits include the following:
a. Weight loss
b. Improvements in cognitive function
c. Gains in energy, strength, stamina, and endurance
d. Reducing the incidence or delaying the onset of many age-relate diseases including cancers, neurological diseases, diabetes
e. Enhances function of the immune system
f. Rapamycin has been shown to reduce the incidence of age-related diseases, including cancer, cognitive decline, neurodegeneration, cardiovascular disease and diabetes